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Defense Intelligence Reference Document Quantum Computing And Utilizing Organic Molecules In Automation Technology

Defense Intelligence Agency · 54 pages · text from the file's own layer

This Defense Intelligence Reference Document from the Defense Intelligence Agency, dated 10 December 2010, is one of a series of advanced technology reports produced in FY 2010 under the Advanced Aerospace Weapon System Applications (AAWSA) Program. It reviews quantum computing technologies and DNA-based molecular computing for onboard supercomputing on future spacecraft. It forecasts ion-trap quantum computers within 10 years, simple DNA tile computing within 20 years, and self-repairing DNA computers on a 40-year horizon.

  • p. 4 …A DNA nanomachine driven by repeated sequential addition of DNA control strands .............................................................................................................. 23 Figure 10. Recombinant…
  • p. 5 …protein molecule decorated with three legs--single-stranded DNAzymes, synthetic DNA molecules that act as enzymes…
  • p. 24 …Set strand ( ·open' \ Waste \ ( 'Closed' Unset strand Figure 9. A DNA nanomachine driven by repeated sequential…
  • p. 25 …Customized strand lengths or oligonucleotides (strands typically 100-200 base pairs long) can be easily ordered…
  • p. 26 …Assembly of DNA motifs with the aid of various branched DNA strands with sticky ends can…
  • p. 27 …This assembly method displaces one DNA strand and selectively replaces it with a strong complementary strand…
  • p. 30 …In this technique, the protection strand is a single oligomer that covers the input side of…
  • p. 32 …1) Single-strand DNAs are immobilized on the surface of a reaction chamber. This provides scaffolds…
  • p. 33 …Single-stranded origami such as William Shih's octahedron (113) cannot, by definition, suffer from this…
  • p. 34 …To hold the scaffold in this shape, helper strands are added to create a regular pattern…
  • p. 36 …In this latest case of DNA computing, inputs are replaced by single-stranded molecules, and how…
  • p. 42 …successive reversible branch migrations of DNA strands, and these strands were called "fuel" and "anti-fuel…
  • p. 45 …protein molecule decorated with three legs--single-stranded DNAzymes, synthetic DNA molecules that act as enzymes…
  • p. 46 …a, The NICK3.4A311 spider consists of a streptavidin core, with a 20-base single-stranded…
  • p. 53 …A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron. Nature, 427(6453…
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Figure 12 (continued). (top a-e) The XOR Cellular Automaton and Its
Implementation by Tile-Based Self-Assembly. (bottom a-e) AFM Images of
Algorithmic Self-assembly of Sierpinski Triangle Crystals.
In theory, this process allows scientists the ability to build a computer from nanoscale
material with DNA tiles (95). The experimental success of this trial demonstrated that 2D
algorithmic self-assembly offers new capabilities for computation and construction, as well as
a new range of physical phenomena and experimental challenges as well.
Error Suppression Mechanisms in DNA Self-Assembly
Molecular self-assembly is an emerging technology that will ultimately enable the fabrication
of great quantities of complex nanoscale objects such as computer circuits at very low costs.
Because the DNA-tile-based bottom-up assembly technique relies on the logic of
programming self-assembly, it requires a situation where sticky-end binding specificity is
infallible. Realistically, however, correctness of matching between tiles cannot be guaranteed
due to the thermodynamics and kinetics of DNA tile self-assembly. This process alone results
in occasional erroneous assembly steps. The number of assembly errors increases with the
number of tile types, and accruing errors render large scale complex computation practically
infeasible.
Assembly errors can be classified into three types: 1.) Growth errors. 2.) Facet errors. 3.)
Nucleation errors. Growth and facet errors are the errors that occur on the growth front of an
existing assembly, while nucleation errors deal with the spurious initiation of assemblies. A
growth error occurs when a DNA tile with one or more mismatched sticky ends is embedded
in the assembly. A facet error occurs on the flat surface (facet) of the aggregate when two
DNA tiles attach on a growth front (facet) side by side, and thus stabilize each other's
binding. This is considered an error because the identity of these tiles may not be correct
with respect to the computation being performed. Nucleation errors are similar to facet errors
in that a number of tiles spontaneously assemble a cluster by stabilizing each other through
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Report, from the dia collection. The PDF is mirrored here; the original link is under it. 54 pages are in the text index: search them above, or from the library's search.