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Defense Intelligence Reference Document Biomaterials

Defense Intelligence Agency · 32 pages · text from the file's own layer

This Defense Intelligence Agency reference document, dated 7 January 2010 and prepared under the Acquisition Threat Support series, surveys biomaterials used in medicine. It covers biocompatibility, biosensor membranes, silicones, Teflon, biodegradable polymers, hydrogels, titanium, bioceramics, tissue constructs, cardiovascular stents, contact lenses, drug delivery and dialysis. It concludes that biomaterial performance underlies many medical devices, that the industry is slow to adopt new materials because of testing costs, and that innovation mainly involves new applications of established materials.

  • p. 9 …different applications In modern society, ranging from water sealants to fibrous insulations. Silicone is often mistakenly…
  • p. 13 …This polymer is hydrophobic (water hating), biologically inert, and nonbiodegradable and also has low friction characteristics…
  • p. 14 …substances that slowly degrade-by evaporation into water vapor and carbon dioxide-when exposed to the…
  • p. 15 …The degradation starts immediately upon water exposure and occurs in two steps. In the first step…
  • p. 17 …rts chemical compatibility, water solubility, nontoxicity, biocompatibility, and multiple physical states allow it be used as…
  • p. 18 …many small empty spaces that can absorb water or other liquids like a sponge. Hydrogels can…
  • p. 25 …When allowed to heat up to body temperature by shutting off the cold water to the…
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Contents
Introduction ............................................................................................................. vi
Imp.ortance of Biocompatlbll1ty ........................................................11:~•········· .................. vii
Science of Biomaterials .....................................................................................vii
Blomaterlals for Biosensors ····"··················· ....................~ ••••••••••••••••••••••••••••••••••••••• 1
Biomaterials for Biomedicine ................................................................................. 2
iv
Biomedical Silicones - Polydimethylsiloxanes .................................................... 2
Silicone Chemistry ..........................................•....................................•................ 4
Silicone In Blomedlcal Products ........................................................•................. 4
Teflon .................................................................................................................. &
Biodegradable Po.lymers ................... ~··· ................................................................... 7
Biodegradation Advantages.................................................................................. 8
Degradable Biomaterials .............................................................................................................. 8
Polylactic Acid and Polyglycolic Acid .................................................................. 8
Polyethylene Glycol or Polyethylene Oxide ........................................................ 10
Hydrogels ............................................................................................................................................................................ 1 o
Titanium - Hip and Knee Joints 11
BioCeramics ................................................................................................................................................................. 11
Denta.1 ceramics .................. IIIJl•IIIJI ....................................................................................................................................................... 13
Tissue Constructs as Biomaterials ......................................................................................................................... 13
Cardiovascular Blomaterlals ...................................................................................................................._..15
Stent Biomaterials .......................................................................................: ................................................... _ts
Nltlnol as a Blomaterlal ............................, ........................................................................ 19
Conta·ct Lenses ........................................................................................................................................ 19
Drug Del Ivery- Polymers.......... .,.......................................................................................■ Ill. 20
Medical Titanium as a Biomaterial ....................................................................................................... 22
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Report, from the dia collection. The PDF is mirrored here; the original link is under it. 32 pages are in the text index: search them above, or from the library's search.