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Defense Intelligence Reference Document Biomaterials

Defense Intelligence Agency · 32 pages · text from the file's own layer

This Defense Intelligence Agency reference document, dated 7 January 2010 and prepared under the Acquisition Threat Support series, surveys biomaterials used in medicine. It covers biocompatibility, biosensor membranes, silicones, Teflon, biodegradable polymers, hydrogels, titanium, bioceramics, tissue constructs, cardiovascular stents, contact lenses, drug delivery and dialysis. It concludes that biomaterial performance underlies many medical devices, that the industry is slow to adopt new materials because of testing costs, and that innovation mainly involves new applications of established materials.

  • p. 4 …Photomicrograph of Titanium Metal (Appears Black in This Photo) in an Intimate Integration With Living Bone…
  • p. 5 UNCLASSIFIED/;'F8A 8FFHillll! U8!! IIU!t Biomaterials Introduction Biomaterials are metals, ceramics, polymers, glasses, carbons, and…
  • p. 6 …For example, the calcium hydroxyapatite coating found on many artificial hips-used as metal-bone interface…
  • p. 7 …A heart valve might be fabricated from polymers, metals, and carbons. A hip joint might be…
  • p. 12 …A tracheostomy tube, or "trach tube," is a 2- to 3-inch-long curved metal or…
  • p. 19 …Bioceramics made from a calcium phosphate material containing tiny pores have been used to coat metal…
  • p. 20 …Full-porcelain (ceramic) dental materials include porcelain, ceramic, or glasslike fillings and crowns (a metal-free…
  • p. 22 …In addition, some metals and ceramics are used in the blood stream. Figure 21 lists some…
  • p. 25 …STENT BIOMATERIALS A stent is a metal mesh tube that looks something like a Chinese finger…
  • p. 26 UNCLASSIFIED;'JFOll 0FFl6ifak W&iE IHIIX NITINOL AS A BIOMATERIAL The use of nitinol metal in…
  • p. 29 …Titanium metal exposed briefly to the atmosphere oxidizes to form a microscopically thin layer of titania…
  • p. 30 UNCLASSIFIED//F0R 8ffl81sllt Y!H!! 9HLY Figure 27, Photomicrograph of Titanium Metal {Appears Black in This…
  • p. 31 …Titanium metal used for implants is usually a biomedical alloy, Ti-6Al-4V, since biomedical alloys…
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Medical Devices Used in the Bloodstream
Blood contact time
Catheters
Guidewires
Sensors
Pacemaker
Vascular Graft
Heart Valve
Stent
Extracorporeal Oxygenation
Artificial Kidney (hemodialyzer)
Total Artificial Heart
Left Ventricular Assist Device (LVAD)
Min-days
Min-hrs
Min-months
10yrs
lifetime
lifetime
lifetime
hrs
hrs
10 yrs
Days-yrs
Figure 2i.. Some of the More Popular Blomedlcal Devices and Duration of Their Blood Contact
Biomaterials. are''used as vascular grafts for art~~Y replacements in.which they are .. _
connected (grafted). onto natural blood vessels at both ends. When arteries, particularly
the coronary arteries and the vessels of the lower limbs, become blocked by fatty
deposits (atherosclerosis), segments in some cases can be replaced with grafts. Figure
22 shows commercial vascular grafts made by Gore Medical (Flagstaff, Arizona, USA).
Figure 22. Gore Medical Teflon Foam Used In Vascular Grafts. These are artificial blood vessels used to
replace blood vessels In the human body damaged by accident, atherothrosclerosls, or diabetic vascular disease.
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Report, from the dia collection. The PDF is mirrored here; the original link is under it. 32 pages are in the text index: search them above, or from the library's search.