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Defense Intelligence Reference Document Biomaterials

Defense Intelligence Agency · 32 pages · text from the file's own layer

This Defense Intelligence Agency reference document, dated 7 January 2010 and prepared under the Acquisition Threat Support series, surveys biomaterials used in medicine. It covers biocompatibility, biosensor membranes, silicones, Teflon, biodegradable polymers, hydrogels, titanium, bioceramics, tissue constructs, cardiovascular stents, contact lenses, drug delivery and dialysis. It concludes that biomaterial performance underlies many medical devices, that the industry is slow to adopt new materials because of testing costs, and that innovation mainly involves new applications of established materials.

  • p. 6 …between biological systems and synthetic or modified natural materials. Biomimetic materials, in contrast, are not made…
  • p. 14 …In the latter, they are used as food wrappings and other packaging derived from natural food…
  • p. 15 …In the second step, the shorter polymer chains are attacked by enzymes that are naturally present…
  • p. 20 …As in natural bone, proteins adsorb to the calcium phosphate surface to provide the critical intervening…
  • p. 23 …onto natural blood vessels at both ends. When arteries, particularly the coronary arteries and the vessels…
  • p. 30 …Using HA in the form of a nanopowder stimulates bone formation leading to a natural, as…
  • p. 32 …lflil 8Hl!:'I Dialysfs works on the principles of natural diffusion of metabolic waste products in…
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can be tailored to varying degrees of hardness and strength for stiffness in catheter
applications.
Biomedical silicones attracted notoriety in 1995 when a class-action lawsuit against
Dow Corning, Inc., brought a huge settlement resulting from the supposed dangers of
silicone breast implants.
After reviewing years of evidence and research concerning silicone gel-filled breast
implants, the national Institute of Medicine found that "evidence suggests diseases or
conditions such as connective tissue diseases, cancer, neurological diseases or other
systemic complaints or conditions are no more common in women with breast implants
than in women without implants." Dow moved out of the medical silicone business and
has since been replaced by an array of smaller companies offering specialized silicone
products.
Figure 4 shows the present form of silicone used for reconstructive surgery following a
mastectomy, particularly after breast cancer in women.
3
Figure 4. Photograph of Silicone (polydimethyllsiloxane) Biomedical Implants Used in Breast
Reconstructive Surgery
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Report, from the dia collection. The PDF is mirrored here; the original link is under it. 32 pages are in the text index: search them above, or from the library's search.